What are treatments for Peyronie’s Disease?

Many patients who develop a bent penis seek a medical treatment. Their goal is correction of the penile curvature. A number of non-surgical treatments have been tried, and continue to be available. In general, these treatments are not highly effective. This is because the curve is generally related to the development of a dense inelastic plaque within the penis. For medication to be effective, these creams, pills, or injections must cause a change in the affected tissue from a dense scar back to elastic supple healthy tissue. To date, no medication has been shown to be highly effective in achieving that goal. The following is a list describing some of the more common treatments.

Vitamin E (400-1200u) (oral)

This vitamin is an antioxidant, and is an inexpensive. It is a common treatment, but there is no proven efficacy.

Colchicine (oral)

This drug is often used to treat gout. Colchicine is an inhibitor of cell division. Cells particularly effected are granulocytes, and these cells are involved in inflammation. Adverse reactions to this medication include gastrointestinal side effects and leukopenia, a lowering of the white blood cell count in the blood.

Potaba (oral)

This medication, composed of potassium p-aminobenzoate is considered an antifibrotic medication, and is thought to prevent fibrosis (scarring) by increasing oxygen uptake at the tissue level. The recommended dose is 4 (0.5gram) tablets or capsules 6 times/day for a period of months. Many patients are discouraged by the number of pills they are asked to take to achieve what is thought to be a possibly effective dose.

Verapamil (penile injection)

Verapamil is a calcium inhibitor, often used to treat hypertension. It is thought that injection of this agent into the area of plaque may alter fibroblast function. Following tissue injury, fibroblasts are cells involved in wound healing.

Pentoxiphylline/Trental (oral 400 mg three times/day)

Pentoxiphylline, a medication used for many years for the treatment of intermittent leg cramping (claudication) has gained recent attention as a potentially effective medical treatment for Peyronie’s disease. The above represents only a partial list of treatments.

Many of our patients with Peyronie’s disease search to find an effective medical treatment. The above and other treatments such as stretching devices have potential benefits, but overall, medical treatment has not been shown to have statistically significant efficacy in randomized clinical trials with good control groups. This is especially true when the criterion for success of a medical treatment is defined as a change from curvature that prevents satisfactory intercourse to functionally insignificant curvature.

At the Center for Reconstructive Urology, many of our patients are referred by their Urologists after being treated with oral medications or injections without success. Some who have very severe disabling curvature and hope we offer a non surgical option that their Urologist has not considered. However, although we do not discourage patients from pursuing any of the above or other treatment options, we do not offer any new experimental treatments at this time. Internet searches related to penile curvature reveal many websites that promote different herbs, creams, pills, and other treatment. When viewing these websites, please understand that the objective is often to sell a product so that the seller makes money. In many cases, the efficacy is overstated. The Center for Reconstructive Urology and Dr. Gelman do not sell any products for profit. We have no financial relationships with pharmaceutical companies or device manufacturers. This website contains no advertising.